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RUNX1–ETO induces a type I interferon response which negatively effects t(8;21)-induced increased self-renewal and leukemia development

The 8;21 translocation is the most common chromosomal aberration occurring in acute myeloid leukemia (AML). This translocation causes expression of the RUNX1–ETO (AML1–ETO) fusion protein, which cooperates with additional mutations in leukemia development. We report here that interferons (IFNs) and...

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Bibliografske podrobnosti
Main Authors: DeKelver, Russell C., Lewin, Benjamin, Weng, Stephanie, Yan, Ming, Biggs, Joseph, Zhang, Dong-Er
Format: Artigo
Jezik:Inglês
Izdano: 2013
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3987666/
https://ncbi.nlm.nih.gov/pubmed/23772668
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3109/10428194.2013.815351
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