Glucocorticoids Inhibit Oncogenic RUNX1-ETO in Acute Myeloid Leukemia with Chromosome Translocation t(8;21)

Acute myeloid leukemia (AML) is a major blood cancer with poor prognosis. New therapies are needed to target oncogene-driven leukemia stem cells, which account for relapse and resistance. Chromosome translocation t(8;21), which produces RUNX1-ETO (R-E) fusion oncoprotein, is found in ~13% AML. R-E d...

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Detalhes bibliográficos
Publicado no:Theranostics
Main Authors: Lu, Lianghao, Wen, Yefei, Yao, Yuan, Chen, Fengju, Wang, Guohui, Wu, Fangrui, Wu, Jingyu, Narayanan, Padmini, Redell, Michele, Mo, Qianxing, Song, Yongcheng
Formato: Artigo
Idioma:Inglês
Publicado em: Ivyspring International Publisher 2018
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Research Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5928880/
https://ncbi.nlm.nih.gov/pubmed/29721072
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7150/thno.22800
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