A Medicinal Chemistry Perspective for Targeting Histone H3 Lysine79 Methyltransferase DOT1L

Por Anglin, Justin L., Song, Yongcheng
Publicado em 2013

Targeting histone methylation for cancer therapy: enzymes, inhibitors, biological activity and perspectives

Por Song, Yongcheng, Wu, Fangrui, Wu, Jingyu
Publicado no J Hematol Oncol (2016)

DOT1L Inhibition Sensitizes MLL-Rearranged AML to Chemotherapy

Por Liu, Wei, Deng, Lisheng, Song, Yongcheng, Redell, Michele
Publicado em 2014

Structures of 1-Deoxy-D-Xylulose-5-Phosphate Reductoisomerase/Lipophilic Phosphonate Complexes

Por Deng, Lisheng, Endo, Kiwamu, Kato, Masahiro, Cheng, Gang, Yajima, Shunsuke, Song, Yongcheng
Publicado em 2010

Expression, Characterization and Inhibition of Toxoplasma gondii 1-Deoxy-D-xylulose-5-phosphate Reductoisomerase

Por Cai, Guobin, Deng, Lisheng, Xue, Jian, Moreno, Silvia N.J., Striepen, Boris, Song, Yongcheng
Publicado em 2013

Synthesis, Activity and Metabolic Stability of Non-Ribose Containing Inhibitors of Histone Methyltransferase DOT1L

Por Deng, Lisheng, Zhang, Li, Yao, Yuan, Wang, Cong, Redell, Michele S., Dong, Shuo, Song, Yongcheng
Publicado em 2013

Antimalarial and Structural Studies of Pyridine-Containing Inhibitors of 1-Deoxyxylulose-5-phosphate Reductoisomerase

Por Xue, Jian, Diao, Jiasheng, Cai, Guobin, Deng, Lisheng, Zheng, Baisong, Yao, Yuan, Song, Yongcheng
Publicado em 2012

3-(Piperidin-4-ylmethoxy)pyridine Containing Compounds Are Potent Inhibitors of Lysine Specific Demethylase 1

Por Wu, Fangrui, Zhou, Chao, Yao, Yuan, Wei, Liping, Feng, Zizhen, Deng, Lisheng, Song, Yongcheng
Publicado no J Med Chem (2015)

Structure activity relationship and modeling studies of inhibitors of lysine specific demethylase 1

Por Zhou, Chao, Wu, Fangrui, Lu, Lianghao, Wei, Liping, Pai, Eric, Yao, Yuan, Song, Yongcheng
Publicado no PLoS One (2017)

Toward Repurposing Ciclopirox as an Antibiotic against Drug-Resistant Acinetobacter baumannii, Escherichia coli, and Klebsiella pneumoniae

Por Carlson-Banning, Kimberly M., Chou, Andrew, Liu, Zhen, Hamill, Richard J., Song, Yongcheng, Zechiedrich, Lynn
Publicado em 2013

Synthesis, Activity and Structure-Activity Relationship of Noroviral Protease Inhibitors

Por Deng, Lisheng, Muhaxhiri, Zana, Estes, Mary K., Palzkill, Timothy, Prasad, B. V. Venkataram, Song, Yongcheng
Publicado em 2013

Targeting TopBP1 at a convergent point of multiple oncogenic pathways for cancer therapy

Por Chowdhury, Pinki, Lin, Gregory E., Liu, Kang, Song, Yongcheng, Lin, Fang-Tsyr, Lin, Weei-Chin
Publicado no Nat Commun (2014)

2-Substituted 4,5-Dihydrothiazole-4-carboxylic Acids Are Novel Inhibitors of Metallo-β-lactamases

Por Chen, Pinhong, Horton, Lori B., Mikulski, Rose L., Deng, Lisheng, Sundriyal, Sandeep, Palzkill, Timothy, Song, Yongcheng
Publicado em 2012

Inhibition of histone H3K79 methylation selectively inhibits proliferation, self-renewal and metastatic potential of breast cancer

Por Zhang, Li, Deng, Lisheng, Chen, Fengju, Yao, Yuan, Wu, Bulan, Wei, Liping, Mo, Qianxing, Song, Yongcheng
Publicado no Oncotarget (2014)

Inhibition of Cancer-Associated Mutant Isocitrate Dehydrogenases by 2-thiohydantoin compounds

Por Wu, Fangrui, Jiang, Hong, Zheng, Baisong, Kogiso, Mari, Yao, Yuan, Zhou, Chao, Li, Xiao-Nan, Song, Yongcheng
Publicado no J Med Chem (2015)

Thermodynamic Investigation of Inhibitor Binding to 1-Deoxy-d-Xylulose-5-Phosphate Reductoisomerase

Por Cai, Guobin, Deng, Lisheng, Fryszczyn, Bartlomiej G., Brown, Nicholas G., Liu, Zhen, Jiang, Hong, Palzkill, Timothy, Song, Yongcheng
Publicado em 2012

Selective Inhibitors of Histone Methyltransferase DOT1L: Design, Synthesis and Crystallographic Studies

Por Yao, Yuan, Chen, Pinhong, Diao, Jiasheng, Cheng, Gang, Deng, Lisheng, Anglin, Justin L., Prasad, B. V. Venkataram, Song, Yongcheng
Publicado em 2011

Structural Basis of Substrate Specificity and Protease Inhibition in Norwalk Virus

Por Muhaxhiri, Zana, Deng, Lisheng, Shanker, Sreejesh, Sankaran, Banumathi, Estes, Mary K., Palzkill, Timothy, Song, Yongcheng, Prasad, B. V. Venkataram
Publicado em 2013

Crystallographic Investigation and Selective Inhibition of Mutant Isocitrate Dehydrogenase

Por Zheng, Baisong, Yao, Yuan, Liu, Zhen, Deng, Lisheng, Anglin, Justin L., Jiang, Hong, Prasad, B. V. Venkataram, Song, Yongcheng
Publicado em 2013

Bisphosphonate inhibitors of ATP-mediated HIV-1 reverse transcriptase catalyzed excision of chain-terminating 3′-azido, 3′-deoxythymidine: A QSAR investigation

Por Song, Yongcheng, Chan, Julian M.W., Tovian, Zev, Secrest, Aaron, Nagy, Eva, Krysiak, Kilannin, Bergan, Kyle, Parniak, Michael A., Oldfield, Eric
Publicado em 2008