Metallo-β-lactamase structure and function

por Palzkill, Timothy
Publicado 2012

Structural and Mechanistic Basis for Extended-Spectrum Drug-Resistance Mutations in Altering the Specificity of TEM, CTX-M, and KPC β-lactamases

por Palzkill, Timothy
Publicado en Front Mol Biosci (2018)

A natural polymorphism in β-lactamase is a global suppressor

por Huang, Wanzhi, Palzkill, Timothy
Publicado 1997

Amino Acid Sequence Requirements at Residues 69 and 238 for the SME-1 β-Lactamase To Confer Resistance to β-Lactam Antibiotics

por Majiduddin, Fahd K., Palzkill, Timothy
Publicado 2003

Amino Acid Residues That Contribute to Substrate Specificity of Class A β-Lactamase SME-1

por Majiduddin, Fahd K., Palzkill, Timothy
Publicado 2005

An analysis of why highly similar enzymes evolve differently.

por Majiduddin, Fahd K, Palzkill, Timothy
Publicado 2003

Identification of residues critical for metallo-β-lactamase function by codon randomization and selection

por Materon, Isabel C., Palzkill, Timothy
Publicado 2001

Systematic substitutions at BLIP position 50 result in changes in binding specificity for class A β-lactamases

por Adamski, Carolyn J., Palzkill, Timothy
Publicado en BMC Biochem (2017)

BLIP-II employs differential hotspot residues to bind structurally similar Staphylococcus aureus PBP2a and class A β-lactamases

por Adamski, Carolyn J., Palzkill, Timothy
Publicado en Biochemistry (2017)

Display of Functional β-Lactamase Inhibitory Protein on the Surface of M13 Bacteriophage

por Huang, Wanzhi, Petrosino, Joseph, Palzkill, Timothy
Publicado 1998

Binding Properties of a Peptide Derived from β-Lactamase Inhibitory Protein

por Rudgers, Gary W., Huang, Wanzhi, Palzkill, Timothy
Publicado 2001

Structural Insight into the Kinetics and ΔCp of Interactions between TEM-1 β-Lactamase and β-Lactamase Inhibitory Protein (BLIP)

por Wang, Jihong, Palzkill, Timothy, Chow, Dar-Chone
Publicado 2009

Neutral β-Lactams Inactivate High Molecular Mass Penicillin-Binding Proteins of Class B1, Including PBP2a of MRSA

por Dave, Kinjal, Palzkill, Timothy, Pratt, R. F.
Publicado 2013

Natural Variants of the KPC-2 Carbapenemase have Evolved Increased Catalytic Efficiency for Ceftazidime Hydrolysis at the Cost of Enzyme Stability

por Mehta, Shrenik C., Rice, Kacie, Palzkill, Timothy
Publicado en PLoS Pathog (2015)

A Fitness Cost Associated With the Antibiotic Resistance Enzyme SME-1 β-Lactamase

por Marciano, David C., Karkouti, Omid Y., Palzkill, Timothy
Publicado 2007

Analysis of the plasticity of location of the Arg244 positive charge within the active site of the TEM-1 β-lactamase

por Marciano, David C, Brown, Nicholas G, Palzkill, Timothy
Publicado 2009

BLIP-II Is a Highly Potent Inhibitor of Klebsiella pneumoniae Carbapenemase (KPC-2)

por Brown, Nicholas G., Chow, Dar-Chone, Palzkill, Timothy
Publicado 2013

How Structural and Physicochemical Determinants Shape Sequence Constraints in a Functional Enzyme

por Abriata, Luciano A., Palzkill, Timothy, Dal Peraro, Matteo
Publicado en PLoS One (2015)

Characterization of the Global Stabilizing Substitution A77V and Its Role in the Evolution of CTX-M β-Lactamases

por Patel, Meha P., Fryszczyn, Bartlomiej G., Palzkill, Timothy
Publicado en Antimicrob Agents Chemother (2015)

Mapping Protein-Protein Interaction Interface Peptides with Jun-Fos Assisted Phage Display and Deep Sequencing

por Huang, Wanzhi, Soeung, Victoria, Boragine, David, Palzkill, Timothy
Publicado en ACS Synth Biol (2020)