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Amino Acid Residues That Contribute to Substrate Specificity of Class A β-Lactamase SME-1

Carbapenem antibiotics are used as antibiotics of last resort because they possess a broad spectrum of antimicrobial activity and are not easily hydrolyzed by β-lactamases. Recently, class A enzymes, such as the SME-1, NMC-A, and IMI-1 β-lactamases, have been identified with the capacity to hydrolyz...

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Detalhes bibliográficos
Main Authors: Majiduddin, Fahd K., Palzkill, Timothy
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2005
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1196253/
https://ncbi.nlm.nih.gov/pubmed/16048956
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.49.8.3421-3427.2005
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