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Identification of residues critical for metallo-β-lactamase function by codon randomization and selection
IMP-1 β-lactamase is a zinc metallo-enzyme encoded by the transferable bla(IMP-1) gene, which confers resistance to virtually all β-lactam antibiotics including carbapenems. To understand how IMP-1 recognizes and hydrolyzes β-lactam antibiotics it is important to determine which amino acid residues...
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| Main Authors: | , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Cold Spring Harbor Laboratory Press
2001
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2374027/ https://ncbi.nlm.nih.gov/pubmed/11714924 |
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