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Identification of residues critical for metallo-β-lactamase function by codon randomization and selection

IMP-1 β-lactamase is a zinc metallo-enzyme encoded by the transferable bla(IMP-1) gene, which confers resistance to virtually all β-lactam antibiotics including carbapenems. To understand how IMP-1 recognizes and hydrolyzes β-lactam antibiotics it is important to determine which amino acid residues...

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Hlavní autoři: Materon, Isabel C., Palzkill, Timothy
Médium: Artigo
Jazyk:Inglês
Vydáno: Cold Spring Harbor Laboratory Press 2001
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2374027/
https://ncbi.nlm.nih.gov/pubmed/11714924
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