Mutagenesis of Zinc Ligand Residue Cys221 Reveals Plasticity in the IMP-1 Metallo-β-Lactamase Active Site

Metallo-β-lactamases catalyze the hydrolysis of a broad range of β-lactam antibiotics and are a concern for the spread of drug resistance. To analyze the determinants of enzyme structure and function, the sequence requirements for the subclass B1 IMP-1 β-lactamase zinc binding residue Cys221 were te...

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Main Authors: Horton, Lori B., Shanker, Sreejesh, Mikulski, Rose, Brown, Nicholas G., Phillips, Kevin J., Lykissa, Ernest, Venkataram Prasad, B. V., Palzkill, Timothy
Format: Artigo
Jezik:Inglês
Izdano: American Society for Microbiology 2012
Teme:
Mechanisms of Resistance
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3486559/
https://ncbi.nlm.nih.gov/pubmed/22908171
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.01276-12
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