2-Substituted 4,5-Dihydrothiazole-4-carboxylic Acids Are Novel Inhibitors of Metallo-β-lactamases

Bacterial resistance to β-lactam antibiotics caused by class B metallo-β-lactamases (MBL), especially for certain hospital-acquired, Gram-negative pathogens, poses a significant threat to public health. We report several 2-substituted 4,5-dihydrothiazole-4-carboxylic acids to be novel MBL inhibitors...

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Autores principales: Chen, Pinhong, Horton, Lori B., Mikulski, Rose L., Deng, Lisheng, Sundriyal, Sandeep, Palzkill, Timothy, Song, Yongcheng
Formato: Artigo
Lenguaje:Inglês
Publicado: 2012
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3463135/
https://ncbi.nlm.nih.gov/pubmed/22921080
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmcl.2012.08.012
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