Structural Basis of Metallo-β-lactamase Inhibition by N-Sulfamoylpyrrole-2-carboxylates

[Image: see text] Metallo-β-lactamases (MBLs) can efficiently catalyze the hydrolysis of all classes of β-lactam antibiotics except monobactams. While serine-β-lactamase (SBL) inhibitors (e.g., clavulanic acid, avibactam) are established for clinical use, no such MBL inhibitors are available. We rep...

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Pubblicato in:ACS Infect Dis
Autori principali: Farley, Alistair J. M., Ermolovich, Yuri, Calvopiña, Karina, Rabe, Patrick, Panduwawala, Tharindi, Brem, Jürgen, Björkling, Fredrik, Schofield, Christopher J.
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Chemical Society 2021
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC8205225/
https://ncbi.nlm.nih.gov/pubmed/34003651
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acsinfecdis.1c00104
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