Bicyclic Boronate VNRX-5133 Inhibits Metallo- and Serine-β-Lactamases

[Image: see text] The bicyclic boronate VNRX-5133 (taniborbactam) is a new type of β-lactamase inhibitor in clinical development. We report that VNRX-5133 inhibits serine-β-lactamases (SBLs) and some clinically important metallo-β-lactamases (MBLs), including NDM-1 and VIM-1/2. VNRX-5133 activity ag...

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Detalhes bibliográficos
Publicado no:J Med Chem
Main Authors: Krajnc, Alen, Brem, Jürgen, Hinchliffe, Philip, Calvopiña, Karina, Panduwawala, Tharindi D., Lang, Pauline A., Kamps, Jos J. A. G., Tyrrell, Jonathan M., Widlake, Emma, Saward, Benjamin G., Walsh, Timothy R., Spencer, James, Schofield, Christopher J.
Formato: Artigo
Idioma:Inglês
Publicado em: American Chemical Society 2019
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6767355/
https://ncbi.nlm.nih.gov/pubmed/31454231
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.jmedchem.9b00911
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