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Will morphing boron-based inhibitors beat the β-lactamases?
The β-lactams remain the most important antibacterials, but their use is increasingly compromised by resistance, importantly by β-lactamases. Although β-lactam and non-β-lactam inhibitors forming stable acyl–enzyme complexes with nucleophilic serine β-lactamases (SBLs) are widely used, these are inc...
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| Veröffentlicht in: | Curr Opin Chem Biol |
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| Hauptverfasser: | , , , , |
| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
Elsevier
2019
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6591701/ https://ncbi.nlm.nih.gov/pubmed/31004962 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cbpa.2019.03.001 |
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