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Will morphing boron-based inhibitors beat the β-lactamases?

The β-lactams remain the most important antibacterials, but their use is increasingly compromised by resistance, importantly by β-lactamases. Although β-lactam and non-β-lactam inhibitors forming stable acyl–enzyme complexes with nucleophilic serine β-lactamases (SBLs) are widely used, these are inc...

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Detalhes bibliográficos
Publicado no:Curr Opin Chem Biol
Main Authors: Krajnc, Alen, Lang, Pauline A, Panduwawala, Tharindi D, Brem, Jürgen, Schofield, Christopher J
Formato: Artigo
Idioma:Inglês
Publicado em: Elsevier 2019
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6591701/
https://ncbi.nlm.nih.gov/pubmed/31004962
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cbpa.2019.03.001
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