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Cyclic boronates as versatile scaffolds for KPC-2 β-lactamase inhibition

Klebsiella pneumoniae carbapenemase-2 (KPC-2) is a serine-β-lactamase (SBL) capable of hydrolysing almost all β-lactam antibiotics. We compare KPC-2 inhibition by vaborbactam, a clinically-approved monocyclic boronate, and VNRX-5133 (taniborbactam), a bicyclic boronate in late-stage clinical develop...

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Publicado en:RSC Med Chem
Autores principales: Tooke, Catherine L., Hinchliffe, Philip, Krajnc, Alen, Mulholland, Adrian J., Brem, Jürgen, Schofield, Christopher J., Spencer, James
Formato: Artigo
Lenguaje:Inglês
Publicado: Royal Society of Chemistry 2020
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Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC7536818/
https://ncbi.nlm.nih.gov/pubmed/33479650
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1039/c9md00557a
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