Bicyclic Boronates as Potent Inhibitors of AmpC, the Class C β-Lactamase from Escherichia coli

Resistance to β-lactam antibacterials, importantly via production of β-lactamases, threatens their widespread use. Bicyclic boronates show promise as clinically useful, dual-action inhibitors of both serine- (SBL) and metallo- (MBL) β-lactamases. In combination with cefepime, the bicyclic boronate t...

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書誌詳細
出版年:Biomolecules
主要な著者: Lang, Pauline A., Parkova, Anete, Leissing, Thomas M., Calvopiña, Karina, Cain, Ricky, Krajnc, Alen, Panduwawala, Tharindi D., Philippe, Jules, Fishwick, Colin W. G., Trapencieris, Peteris, Page, Malcolm G. P., Schofield, Christopher J., Brem, Jürgen
フォーマット: Artigo
言語:Inglês
出版事項: MDPI 2020
主題:
Article
オンライン･アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC7356297/
https://ncbi.nlm.nih.gov/pubmed/32545682
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/biom10060899
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