Faropenem reacts with serine and metallo-β-lactamases to give multiple products

Penems have demonstrated potential as antibacterials and β-lactamase inhibitors; however, their clinical use has been limited, especially in comparison with the structurally related carbapenems. Faropenem is an orally active antibiotic with a C2 tetrahydrofuran (THF) ring, which is resistant to hydr...

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Vydáno v:Eur J Med Chem
Hlavní autoři: Lucic, Anka, Hinchliffe, Philip, Malla, Tika R., Tooke, Catherine L., Brem, Jürgen, Calvopiña, Karina, Lohans, Christopher T., Rabe, Patrick, McDonough, Michael A., Armistead, Timothy, Orville, Allen M., Spencer, James, Schofield, Christopher J.
Médium: Artigo
Jazyk:Inglês
Vydáno: 2021
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7614720/
https://ncbi.nlm.nih.gov/pubmed/33618159
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ejmech.2021.113257
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