Structural Basis of Metallo-β-Lactamase Inhibition by Captopril Stereoisomers

β-Lactams are the most successful antibacterials, but their effectiveness is threatened by resistance, most importantly by production of serine- and metallo-β-lactamases (MBLs). MBLs are of increasing concern because they catalyze the hydrolysis of almost all β-lactam antibiotics, including recent-g...

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Bibliografiske detaljer
Udgivet i:Antimicrob Agents Chemother
Main Authors: Brem, Jürgen, van Berkel, Sander S., Zollman, David, Lee, Sook Y., Gileadi, Opher, McHugh, Peter J., Walsh, Timothy R., McDonough, Michael A., Schofield, Christopher J.
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Microbiology 2015
Fag:
Mechanisms of Resistance
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4704194/
https://ncbi.nlm.nih.gov/pubmed/26482303
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.01335-15
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