Structural Insight into the Kinetics and ΔCp of Interactions between TEM-1 β-Lactamase and β-Lactamase Inhibitory Protein (BLIP)

Por Wang, Jihong, Palzkill, Timothy, Chow, Dar-Chone
Publicado em 2009

BLIP-II Is a Highly Potent Inhibitor of Klebsiella pneumoniae Carbapenemase (KPC-2)

Por Brown, Nicholas G., Chow, Dar-Chone, Palzkill, Timothy
Publicado em 2013

Fine mapping of the sequence requirements for binding of β-lactamase inhibitory protein (BLIP) to TEM-1 β-lactamase using a genetic screen for BLIP function

Por Yuan, Ji, Huang, Wanzhi, Chow, Dar-Chone, Palzkill, Timothy
Publicado em 2009

Identification of a β-lactamase inhibitory protein variant that is a potent inhibitor of Staphylococcus PC1 β-lactamase

Por Yuan, Ji, Chow, Dar-Chone, Huang, Wanzhi, Palzkill, Timothy
Publicado em 2011

Identification of the β-Lactamase Inhibitor Protein-II (BLIP-II) Interface Residues Essential for Binding Affinity and Specificity for Class A β-Lactamases

Por Brown, Nicholas G., Chow, Dar-Chone, Ruprecht, Kevin E., Palzkill, Timothy
Publicado em 2013

Engineering specificity from broad to narrow: Design of a BLIP variant that exclusively binds and detects KPC β-lactamase

Por Chow, Dar-Chone, Rice, Kacie, Huang, Wanzhi, Atmar, Robert L., Palzkill, Timothy
Publicado no ACS Infect Dis (2016)

Analysis of the Binding Forces Driving the Tight Interactions between β-Lactamase Inhibitory Protein-II (BLIP-II) and Class A β-Lactamases

Por Brown, Nicholas G., Chow, Dar-Chone, Sankaran, Banumathi, Zwart, Peter, Prasad, B. V. Venkataram, Palzkill, Timothy
Publicado em 2011

Crystallographic Analysis of Rotavirus NSP2-RNA Complex Reveals Specific Recognition of 5′ GG Sequence for RTPase Activity

Por Hu, Liya, Chow, Dar-Chone, Patton, John T., Palzkill, Timothy, Estes, Mary K., Prasad, B. V. Venkataram
Publicado em 2012

Small Molecule Inhibition of the Steroid Receptor Coactivators, SRC-3 and SRC-1

Por Wang, Ying, Lonard, David M., Yu, Yang, Chow, Dar-Chone, Palzkill, Timothy G., O'Malley, Bert W.
Publicado em 2011

A Triple Mutant in the Ω-loop of TEM-1 β-Lactamase Changes the Substrate Profile via a Large Conformational Change and an Altered General Base for Catalysis

Por Stojanoski, Vlatko, Chow, Dar-Chone, Hu, Liya, Sankaran, Banumathi, Gilbert, Hiram F., Prasad, B. V. Venkataram, Palzkill, Timothy
Publicado no J Biol Chem (2015)

Structural Basis for Different Substrate Profiles of Two Closely Related Class D β-lactamases and Their Inhibition by Halogens

Por Stojanoski, Vlatko, Chow, Dar-Chone, Fryszczyn, Bartlomiej, Hu, Liya, Nordmann, Patrice, Poirel, Laurent, Sankaran, Banumathi, Prasad, B. V. Venkataram, Palzkill, Timothy
Publicado no Biochemistry (2015)

Probing the Sites of Interactions of Rotaviral Proteins Involved in Replication

Por Viskovska, Maria, Anish, Ramakrishnan, Hu, Liya, Chow, Dar-Chone, Hurwitz, Amy M., Brown, Nicholas G., Palzkill, Timothy, Estes, Mary K., Prasad, B. V. Venkataram
Publicado no J Virol (2014)

Identification of Verrucarin A as a Potent and Selective Steroid Receptor Coactivator-3 Small Molecule Inhibitor

Por Yan, Fei, Yu, Yang, Chow, Dar-Chone, Palzkill, Timothy, Madoux, Franck, Hodder, Peter, Chase, Peter, Griffin, Patrick R., O'Malley, Bert W., Lonard, David M.
Publicado em 2014

MalE of Group A Streptococcus Participates in the Rapid Transport of Maltotriose and Longer Maltodextrins

Por Shelburne, Samuel A., Fang, Han, Okorafor, Nnaja, Sumby, Paul, Sitkiewicz, Izabela, Keith, David, Patel, Payal, Austin, Celest, Graviss, Edward A., Musser, James M., Chow, Dar-Chone
Publicado em 2007

Development of potent small-molecule inhibitors to drug the undruggable steroid receptor coactivator-3

Por Song, Xianzhou, Chen, Jianwei, Zhao, Mingkun, Zhang, Chengwei, Yu, Yang, Lonard, David M., Chow, Dar-Chone, Palzkill, Timothy, Xu, Jianming, O’Malley, Bert W., Wang, Jin
Publicado no Proc Natl Acad Sci U S A (2016)

Generation and Characterization of Antibodies against Asian Elephant (Elephas maximus) IgG, IgM, and IgA

Por Humphreys, Alan F., Tan, Jie, Peng, RongSheng, Benton, Susan M., Qin, Xiang, Worley, Kim C., Mikulski, Rose L., Chow, Dar-Chone, Palzkill, Timothy G., Ling, Paul D.
Publicado no PLoS One (2015)

Co-Crystal Structures of PKG Iβ (92–227) with cGMP and cAMP Reveal the Molecular Details of Cyclic-Nucleotide Binding

Por Kim, Jeong Joo, Casteel, Darren E., Huang, Gilbert, Kwon, Taek Hun, Ren, Ronnie Kuo, Zwart, Peter, Headd, Jeffrey J., Brown, Nicholas Gene, Chow, Dar-Chone, Palzkill, Timothy, Kim, Choel
Publicado em 2011

The crystal structures of PKG Iβ (92-227) with cGMP and cAMP reveal the molecular details of cyclic-nucleotide binding

Por Kim, Jeong Joo, Casteel, Darren E, Huang, Gilbert, Kwon, Taek Hun, Ren, Ronnie Kuo, Zwart, Peter, Headd, Jeffrey J, Brown, Nicholas Gene, Chow, Dar-Chone, Palzkill, Timothy, Kim, Choel
Publicado em 2011

Characterization of a steroid receptor coactivator small molecule stimulator that over-stimulates cancer cells, leading to cell stress and death

Por Wang, Lei, Yu, Yang, Chow, Dar-Chone, Yan, Fei, Hsu, Chih-Chao, Stossi, Fabio, Mancini, Michael A., Palzkill, Timothy, Liao, Lan, Zhou, Suoling, Xu, Jianming, Lonard, David M., O’Malley, Bert W.
Publicado no Cancer Cell (2015)

Bufalin is a potent small molecule inhibitor of the steroid receptor coactivators SRC-3 and SRC-1

Por Wang, Ying, Lonard, David M., Yu, Yang, Chow, Dar-Chone, Palzkill, Timothy G., Wang, Jin, Qi, Ruogu, Matzuk, Alexander J., Song, Xianzhou, Madoux, Franck, Hodder, Peter, Chase, Peter, Griffin, Patrick R., Zhou, Suoling, Liao, Lan, Xu, Jianming, O’Malley, Bert W.
Publicado em 2014