Development of potent small-molecule inhibitors to drug the undruggable steroid receptor coactivator-3

Protein–protein interactions (PPIs) play a central role in most biological processes, and therefore represent an important class of targets for therapeutic development. However, disrupting PPIs using small-molecule inhibitors (SMIs) is challenging and often deemed as “undruggable.” We developed a ce...

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Detalhes bibliográficos
Publicado no:Proc Natl Acad Sci U S A
Main Authors: Song, Xianzhou, Chen, Jianwei, Zhao, Mingkun, Zhang, Chengwei, Yu, Yang, Lonard, David M., Chow, Dar-Chone, Palzkill, Timothy, Xu, Jianming, O’Malley, Bert W., Wang, Jin
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2016
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4983835/
https://ncbi.nlm.nih.gov/pubmed/27084884
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1604274113
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