Characterization of a steroid receptor coactivator small molecule stimulator that over-stimulates cancer cells, leading to cell stress and death

By integrating growth pathways that cancer cells rely on, steroid receptor coactivators (SRC-1, SRC-2, SRC-3) represent emerging targets in cancer therapeutics. High throughput screening for SRC small molecule inhibitors (SMI) uncovered MCB-613 as a potent SRC small molecule ‘stimulator’ (SMS). We d...

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Detalhes bibliográficos
Publicado no:Cancer Cell
Main Authors: Wang, Lei, Yu, Yang, Chow, Dar-Chone, Yan, Fei, Hsu, Chih-Chao, Stossi, Fabio, Mancini, Michael A., Palzkill, Timothy, Liao, Lan, Zhou, Suoling, Xu, Jianming, Lonard, David M., O’Malley, Bert W.
Formato: Artigo
Idioma:Inglês
Publicado em: 2015
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4536575/
https://ncbi.nlm.nih.gov/pubmed/26267537
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ccell.2015.07.005
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