Crystallographic Analysis of Rotavirus NSP2-RNA Complex Reveals Specific Recognition of 5′ GG Sequence for RTPase Activity

Rotavirus nonstructural protein NSP2, a functional octamer, is critical for the formation of viroplasms, which are exclusive sites for replication and packaging of the segmented double-stranded RNA (dsRNA) rotavirus genome. As a component of replication intermediates, NSP2 is also implicated in vari...

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Bibliografiska uppgifter
Huvudupphovsmän: Hu, Liya, Chow, Dar-Chone, Patton, John T., Palzkill, Timothy, Estes, Mary K., Prasad, B. V. Venkataram
Materialtyp: Artigo
Språk:Inglês
Publicerad: American Society for Microbiology 2012
Ämnen:
Structure and Assembly
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC3457270/
https://ncbi.nlm.nih.gov/pubmed/22811529
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.01201-12
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