Crystallographic and Biochemical Analysis of Rotavirus NSP2 with Nucleotides Reveals a Nucleoside Diphosphate Kinase-Like Activity

Rotavirus, the major pathogen of infantile gastroenteritis, carries a nonstructural protein, NSP2, essential for viroplasm formation and genome replication/packaging. In addition to RNA-binding and helix-destabilizing properties, NSP2 exhibits nucleoside triphosphatase activity. A conserved histidin...

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Detalhes bibliográficos
Main Authors: Kumar, Mukesh, Jayaram, Hariharan, Vasquez-Del Carpio, Rodrigo, Jiang, Xiaofang, Taraporewala, Zenobia F., Jacobson, Raymond H., Patton, John T., Prasad, B. V. Venkataram
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology (ASM) 2007
Assuntos:
Structure and Assembly
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2168982/
https://ncbi.nlm.nih.gov/pubmed/17804496
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.00984-07
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