Analysis of the Binding Forces Driving the Tight Interactions between β-Lactamase Inhibitory Protein-II (BLIP-II) and Class A β-Lactamases

β-Lactamases hydrolyze β-lactam antibiotics to provide drug resistance to bacteria. β-Lactamase inhibitory protein-II (BLIP-II) is a potent proteinaceous inhibitor that exhibits low picomolar affinity for class A β-lactamases. This study examines the driving forces for binding between BLIP-II and β-...

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Detalhes bibliográficos
Main Authors: Brown, Nicholas G., Chow, Dar-Chone, Sankaran, Banumathi, Zwart, Peter, Prasad, B. V. Venkataram, Palzkill, Timothy
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2011
Assuntos:
Protein Structure and Folding
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3173220/
https://ncbi.nlm.nih.gov/pubmed/21775426
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M111.265058
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