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Systematic substitutions at BLIP position 50 result in changes in binding specificity for class A β-lactamases

BACKGROUND: The production of β-lactamases by bacteria is the most common mechanism of resistance to the widely prescribed β-lactam antibiotics. β-lactamase inhibitory protein (BLIP) competitively inhibits class A β-lactamases via two binding loops that occlude the active site. It has been shown tha...

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Publicat a:BMC Biochem
Autors principals: Adamski, Carolyn J., Palzkill, Timothy
Format: Artigo
Idioma:Inglês
Publicat: BioMed Central 2017
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5340008/
https://ncbi.nlm.nih.gov/pubmed/28264645
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12858-017-0077-1
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