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Systematic substitutions at BLIP position 50 result in changes in binding specificity for class A β-lactamases
BACKGROUND: The production of β-lactamases by bacteria is the most common mechanism of resistance to the widely prescribed β-lactam antibiotics. β-lactamase inhibitory protein (BLIP) competitively inhibits class A β-lactamases via two binding loops that occlude the active site. It has been shown tha...
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| Publié dans: | BMC Biochem |
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| Auteurs principaux: | , |
| Format: | Artigo |
| Langue: | Inglês |
| Publié: |
BioMed Central
2017
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| Sujets: | |
| Accès en ligne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5340008/ https://ncbi.nlm.nih.gov/pubmed/28264645 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12858-017-0077-1 |
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