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Structures of 1-Deoxy-D-Xylulose-5-Phosphate Reductoisomerase/Lipophilic Phosphonate Complexes
[Image: see text] Fosmidomycin, a potent inhibitor of 1-deoxy-d-xylulose-5-phosphate reductoisomerase (DXR), has antibacterial and antimalaria activity. Due to its poor pharmacokinetics, more lipophilic DXR inhibitors are needed. However, the hydrophobic binding site(s) in DXR remains elusive. Here,...
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| Main Authors: | , , , , , |
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| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
American Chemical Society
2010
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| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3046873/ https://ncbi.nlm.nih.gov/pubmed/21379374 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ml100243r |
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