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Structures of 1-Deoxy-D-Xylulose-5-Phosphate Reductoisomerase/Lipophilic Phosphonate Complexes

[Image: see text] Fosmidomycin, a potent inhibitor of 1-deoxy-d-xylulose-5-phosphate reductoisomerase (DXR), has antibacterial and antimalaria activity. Due to its poor pharmacokinetics, more lipophilic DXR inhibitors are needed. However, the hydrophobic binding site(s) in DXR remains elusive. Here,...

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Bibliografiske detaljer
Main Authors: Deng, Lisheng, Endo, Kiwamu, Kato, Masahiro, Cheng, Gang, Yajima, Shunsuke, Song, Yongcheng
Format: Artigo
Sprog:Inglês
Udgivet: American Chemical Society 2010
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3046873/
https://ncbi.nlm.nih.gov/pubmed/21379374
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ml100243r
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