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Structure of 1-deoxy-d-xylulose 5-phosphate reductoisomerase in a quaternary complex with a magnesium ion, NADPH and the antimalarial drug fosmidomycin

The crystal structure of 1-deoxy-d-xylulose 5-phosphate reductoisomerase (DXR) from Escherichia coli complexed with Mg(2+), NADPH and fosmidomycin was solved at 2.2 Å resolution. DXR is the key enzyme in the 2-­C-methyl-d-­erythritol 4-phosphate pathway and is an effective target of antimalarial dru...

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Detaylı Bibliyografya
Asıl Yazarlar: Yajima, Shunsuke, Hara, Kodai, Iino, Daisuke, Sasaki, Yasuyuki, Kuzuyama, Tomohisa, Ohsawa, Kanju, Seto, Haruo
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: International Union of Crystallography 2007
Konular:
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC2335089/
https://ncbi.nlm.nih.gov/pubmed/17554164
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1107/S1744309107024475
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