Alteration of the Flexible Loop in 1-Deoxy-d-xylulose-5-phosphate Reductoisomerase Boosts Enthalpy-Driven Inhibition by Fosmidomycin

[Image: see text] 1-Deoxy-d-xylulose-5-phosphate reductoisomerase (DXR), which catalyzes the first committed step in the 2-C-methyl-d-erythritol 4-phosphate pathway of isoprenoid biosynthesis used by Mycobacterium tuberculosis and other infectious microorganisms, is absent in humans and therefore an...

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Bibliographic Details
Main Authors: Kholodar, Svetlana A., Tombline, Gregory, Liu, Juan, Tan, Zhesen, Allen, C. Leigh, Gulick, Andrew M., Murkin, Andrew S.
Format: Artigo
Language:Inglês
Published: American Chemical Society 2014
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4045324/
https://ncbi.nlm.nih.gov/pubmed/24825256
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bi5004074
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