1-Deoxy-d-Xylulose 5-Phosphate Reductoisomerase (IspC) from Mycobacterium tuberculosis: towards Understanding Mycobacterial Resistance to Fosmidomycin

1-Deoxy-d-xylulose 5-phosphate reductoisomerase (IspC) catalyzes the first committed step in the mevalonate-independent isopentenyl diphosphate biosynthetic pathway and is a potential drug target in some pathogenic bacteria. The antibiotic fosmidomycin has been shown to inhibit IspC in a number of o...

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Autors principals: Dhiman, Rakesh K., Schaeffer, Merrill L., Bailey, Ann Marie, Testa, Charles A., Scherman, Hataichanok, Crick, Dean C.
Format: Artigo
Idioma:Inglês
Publicat: American Society for Microbiology 2005
Matèries:
Molecular Biology of Pathogens
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC1316992/
https://ncbi.nlm.nih.gov/pubmed/16321944
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JB.187.24.8395-8402.2005
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