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Structures of 1-Deoxy-D-Xylulose-5-Phosphate Reductoisomerase/Lipophilic Phosphonate Complexes
[Image: see text] Fosmidomycin, a potent inhibitor of 1-deoxy-d-xylulose-5-phosphate reductoisomerase (DXR), has antibacterial and antimalaria activity. Due to its poor pharmacokinetics, more lipophilic DXR inhibitors are needed. However, the hydrophobic binding site(s) in DXR remains elusive. Here,...
Wedi'i Gadw mewn:
| Prif Awduron: | , , , , , |
|---|---|
| Fformat: | Artigo |
| Iaith: | Inglês |
| Cyhoeddwyd: |
American Chemical Society
2010
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| Mynediad Ar-lein: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3046873/ https://ncbi.nlm.nih.gov/pubmed/21379374 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ml100243r |
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