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A Medicinal Chemistry Perspective for Targeting Histone H3 Lysine79 Methyltransferase DOT1L
Histone H3 lysine79 (H3K79) methyltransferase DOT1L plays an important role in the activation and maintenance of gene transcription. It is essential for embryonic development as well as normal functions of the hematopoietic system, heart and kidney in adults. DOT1L has been found to be a drug target...
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| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
2013
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4109313/ https://ncbi.nlm.nih.gov/pubmed/23879463 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jm4007752 |
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