Heritable Targeted Gene Disruption in Zebrafish Using Designed Zinc Finger Nucleases

We describe here the use of zinc finger nucleases (ZFNs) for somatic and germline disruption of genes in zebrafish (Danio rerio), where targeted mutagenesis was previously intractable. ZFNs induce a targeted double-strand break in the genome that is repaired to generate small insertions and deletion...

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Detalhes bibliográficos
Main Authors: Doyon, Yannick, McCammon, Jasmine M, Miller, Jeffrey C, Faraji, Farhoud, Ngo, Catherine, Katibah, George E, Amora, Rainier, Hocking, Toby D, Zhang, Lei, Rebar, Edward J, Gregory, Philip D, Urnov, Fyodor D, Amacher, Sharon L
Formato: Artigo
Idioma:Inglês
Publicado em: 2008
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2674762/
https://ncbi.nlm.nih.gov/pubmed/18500334
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nbt1409
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