Efficient targeted gene disruption in the soma and germ line of the frog Xenopus tropicalis using engineered zinc-finger nucleases

The frog Xenopus, an important research organism in cell and developmental biology, currently lacks tools for targeted mutagenesis. Here, we address this problem by genome editing with zinc-finger nucleases (ZFNs). ZFNs directed against an eGFP transgene in Xenopus tropicalis induced mutations consi...

Fuld beskrivelse

Na minha lista:
Bibliografiske detaljer
Main Authors: Young, John J., Cherone, Jennifer M., Doyon, Yannick, Ankoudinova, Irina, Faraji, Farhoud M., Lee, Andrew H., Ngo, Catherine, Guschin, Dmitry Y., Paschon, David E., Miller, Jeffrey C., Zhang, Lei, Rebar, Edward J., Gregory, Philip D., Urnov, Fyodor D., Harland, Richard M., Zeitler, Bryan
Format: Artigo
Sprog:Inglês
Udgivet: National Academy of Sciences 2011
Fag:
Biological Sciences
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3084115/
https://ncbi.nlm.nih.gov/pubmed/21471457
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1102030108
Tags: Tilføj Tag
Ingen Tags, Vær først til at tagge denne postø!

Lignende værker