Glial-derived neurotrophic factor gene transfer for Parkinson’s disease: Anterograde distribution of AAV2 vectors in the primate brain

por Kells, Adrian P., Forsayeth, John, Bankiewicz, Krystof S.
Publicado 2011

Gene Therapy for Misfolding Protein Diseases of the Central Nervous System

por San Sebastian, Waldy, Samaranch, Lluis, Kells, Adrian P., Forsayeth, John, Bankiewicz, Krystof S.
Publicado 2013

Safety Assessment of AAV2-hGDNF Administered via Intra-Cerebral Injection in Rats for treatment of Parkinson’s Disease.

por Terse, Pramod S., Kells, Adrian P., Noker, Patricia, Wright, J Fraser, Bankiewicz, Krystof S.
Publicado en Int J Toxicol (2020)

Anterograde Axonal Transport of AAV2-GDNF in Rat Basal Ganglia

por Ciesielska, Agnieszka, Mittermeyer, Gabriele, Hadaczek, Piotr, Kells, Adrian P, Forsayeth, John, Bankiewicz, Krystof S
Publicado 2011

Efficient gene therapy-based method for the delivery of therapeutics to primate cortex

por Kells, Adrian P., Hadaczek, Piotr, Yin, Dali, Bringas, John, Varenika, Vanja, Forsayeth, John, Bankiewicz, Krystof S.
Publicado 2009

Strong Cortical and Spinal Cord Transduction After AAV7 and AAV9 Delivery into the Cerebrospinal Fluid of Nonhuman Primates

por Samaranch, Lluis, Salegio, Ernesto A., San Sebastian, Waldy, Kells, Adrian P., Bringas, John R., Forsayeth, John, Bankiewicz, Krystof S.
Publicado 2013

ADENO-ASSOCIATED VIRUS TYPE 6 IS RETROGRADELY TRANSPORTED IN THE NON-HUMAN PRIMATE BRAIN

por Sebastian, Waldy San, Samaranch, Lluis, Heller, Gregory, Kells, Adrian P., Bringas, John, Pivirotto, Phillip, Forsayeth, John, Bankiewicz, Krystof S.
Publicado 2013

Functional Effects of AAV2-GDNF on the Dopaminergic Nigrostriatal Pathway in Parkinsonian Rhesus Monkeys

por Eberling, Jamie L., Kells, Adrian P., Pivirotto, Philip, Beyer, Janine, Bringas, John, Federoff, Howard J., Forsayeth, John, Bankiewicz, Krystof S.
Publicado 2009

Automated Segmentation Tool for Brain Infusions

por Rosenbluth, Kathryn Hammond, Gimenez, Francisco, Kells, Adrian P., Salegio, Ernesto A., Mittermeyer, Gabriele M., Modera, Kevin, Kohal, Anmol, Bankiewicz, Krystof S.
Publicado 2013

An alpha-synuclein AAV gene silencing vector ameliorates a behavioral deficit in a rat model of Parkinson’s disease, but displays toxicity in dopamine neurons

por Khodr, Christina E., Sapru, Mohan K., Pedapati, Jyothi, Han, Ye, West, Neva C., Kells, Adrian P., Bankiewicz, Krystof S., Bohn, Martha C.
Publicado 2011

Axonal transport of adeno-associated viral vectors is serotype-dependent

por Salegio, Ernesto A., Samaranch, Lluis, Kells, Adrian P., Mittermeyer, Gabriele, San Sebastian, Waldy, Zhou, Shangzhen, Beyer, Janine, Forsayeth, John, Bankiewicz, Krystof S.
Publicado 2012

Real-time MR Imaging With Gadoteridol Predicts Distribution of Transgenes After Convection-enhanced Delivery of AAV2 Vectors

por Su, Xiaomin, Kells, Adrian P, Aguilar Salegio, Ernesto A, Richardson, R Mark, Hadaczek, Piotr, Beyer, Janine, Bringas, John, Pivirotto, Philip, Forsayeth, John, Bankiewicz, Krystof S
Publicado 2010

Advances in Thin Tissue Golgi-Cox Impregnation: Fast, Reliable Methods for Multi-Assay Analyses in Rodent and Non-human Primate Brain

por Levine, Nathan D., Rademacher, David J., Collier, Timothy J., O’Malley, Jennifer A., Kells, Adrian P., Sebastian, Waldy San, Bankiewicz, Krystof S., Steece-Collier, Kathy
Publicado 2013

Convection-enhanced delivery improves distribution and efficacy of tumor-selective retroviral replicating vectors (RRV) in a rodent brain tumor model

por Yin, Dali, Zhai, Yuying, Gruber, Harry E., Ibanez, Carlos E., Robbins, Joan M., Kells, Adrian P., Kasahara, Noriyuki, Forsayeth, John, Jolly, Douglas J., Bankiewicz, Krystof S.
Publicado 2013

AAV9-mediated Expression of a Non-self Protein in Nonhuman Primate Central Nervous System Triggers Widespread Neuroinflammation Driven by Antigen-presenting Cell Transduction

por Samaranch, Lluis, Sebastian, Waldy San, Kells, Adrian P, Salegio, Ernesto A, Heller, Gregory, Bringas, John R, Pivirotto, Philip, DeArmond, Stephen, Forsayeth, John, Bankiewicz, Krystof S
Publicado 2014

Regeneration of the MPTP-Lesioned Dopaminergic System after Convection-Enhanced Delivery of AAV2-GDNF

por Kells, Adrian P., Eberling, Jamie, Su, Xiaomin, Pivirotto, Philip, Bringas, John, Hadaczek, Piotr, Narrow, Wade C., Bowers, William J., Federoff, Howard J., Forsayeth, John, Bankiewicz, Krystof S.
Publicado 2010

Safety and Tolerability of Magnetic Resonance Imaging-Guided Convection-Enhanced Delivery of AAV2-hAADC with a Novel Delivery Platform in Nonhuman Primate Striatum

por San Sebastian, Waldy, Richardson, R. Mark, Kells, Adrian P., Lamarre, Clementine, Bringas, John, Pivirotto, Philip, Salegio, Ernesto A., DeArmond, Stephen J., Forsayeth, John, Bankiewicz, Krystof S.
Publicado 2012

Adeno-Associated Virus Serotype 9 Transduction in the Central Nervous System of Nonhuman Primates

por Samaranch, Lluis, Salegio, Ernesto A., San Sebastian, Waldy, Kells, Adrian P., Foust, Kevin D., Bringas, John R., Lamarre, Clementine, Forsayeth, John, Kaspar, Brian K., Bankiewicz, Krystof S.
Publicado 2011

Distribution of nanoparticles throughout the cerebral cortex of rodents and non-human primates: Implications for gene and drug therapy

por Salegio, Ernesto A., Streeter, Hillary, Dube, Nikhil, Hadaczek, Piotr, Samaranch, Lluis, Kells, Adrian P., San Sebastian, Waldy, Zhai, Yuying, Bringas, John, Xu, Ting, Forsayeth, John, Bankiewicz, Krystof S.
Publicado 2014

Safety Evaluation of AAV2-GDNF Gene Transfer into the Dopaminergic Nigrostriatal Pathway in Aged and Parkinsonian Rhesus Monkeys

por Su, Xiaomin, Kells, Adrian P., Huang, Eric J., Lee, Han S., Hadaczek, Piotr, Beyer, Janine, Bringas, John, Pivirotto, Philip, Penticuff, Janine, Eberling, Jamie, Federoff, Howard J., Forsayeth, John, Bankiewicz, Krystof S.
Publicado 2009