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Glial-derived neurotrophic factor gene transfer for Parkinson’s disease: Anterograde distribution of AAV2 vectors in the primate brain

Delivery of neurotrophic factors to treat neurodegenerative diseases has not been efficacious in clinical trials despite their known potency for promoting neuronal growth and survival. Direct gene delivery to the brain offers an approach for establishing sustained expression of neurotrophic factors...

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Detalhes bibliográficos
Main Authors: Kells, Adrian P., Forsayeth, John, Bankiewicz, Krystof S.
Formato: Artigo
Idioma:Inglês
Publicado em: 2011
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3289735/
https://ncbi.nlm.nih.gov/pubmed/22019719
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.nbd.2011.10.004
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