Safety and Tolerability of Magnetic Resonance Imaging-Guided Convection-Enhanced Delivery of AAV2-hAADC with a Novel Delivery Platform in Nonhuman Primate Striatum

Degeneration of nigrostriatal neurons in Parkinson's disease (PD) causes progressive loss of aromatic l-amino acid decarboxylase (AADC), the enzyme that converts levodopa (l-DOPA) into dopamine in the striatum. Because loss of this enzyme appears to be a major driver of progressive impairment o...

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Detalhes bibliográficos
Main Authors: San Sebastian, Waldy, Richardson, R. Mark, Kells, Adrian P., Lamarre, Clementine, Bringas, John, Pivirotto, Philip, Salegio, Ernesto A., DeArmond, Stephen J., Forsayeth, John, Bankiewicz, Krystof S.
Formato: Artigo
Idioma:Inglês
Publicado em: Mary Ann Liebert, Inc. 2012
Assuntos:
Research Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3277736/
https://ncbi.nlm.nih.gov/pubmed/22017504
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1089/hum.2011.162
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