Eight Years of Clinical Improvement in MPTP-Lesioned Primates After Gene Therapy With AAV2-hAADC

This study completes the longest known in vivo monitoring of adeno-associated virus (AAV)–mediated gene expression in nonhuman primate (NHP) brain. Although six of the eight parkinsonian NHP originally on study have undergone postmortem analysis, as described previously, we monitored the remaining t...

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Autori principali: Hadaczek, Piotr, Eberling, Jamie L, Pivirotto, Philip, Bringas, John, Forsayeth, John, Bankiewicz, Krystof S
Natura: Artigo
Lingua:Inglês
Pubblicazione: Nature Publishing Group 2010
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Original Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2927057/
https://ncbi.nlm.nih.gov/pubmed/20531394
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/mt.2010.106
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