A Dose-Ranging Study of AAV-hAADC Therapy in Parkinsonian Monkeys

The main medication for idiopathic Parkinson disease is l-Dopa. Drug efficacy declines steadily in part because the converting enzyme, aromatic l-amino acid decarboxylase (AADC), is lost concomitant with substantia nigra atrophy. Over the past decade, we have developed a gene therapy approach in whi...

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Autors principals: Forsayeth, John R., Eberling, Jamie L., Sanftner, Laura M., Zhen, Zhu, Pivirotto, Philip, Bringas, John, Cunningham, Janet, Bankiewicz, Krystof S.
Format: Artigo
Idioma:Inglês
Publicat: 2006
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2725179/
https://ncbi.nlm.nih.gov/pubmed/16781894
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ymthe.2006.04.008
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