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Functional Effects of AAV2-GDNF on the Dopaminergic Nigrostriatal Pathway in Parkinsonian Rhesus Monkeys

We investigated the safety and neuroregenerative potential of an adeno-associated virus (AAV2) containing human glial cell line-derived neurotrophic factor (GDNF) in an MPTP primate model of Parkinson's disease. Dopaminergic function was evaluated by positron emission tomography with 6-[(18)F]f...

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Dettagli Bibliografici
Autori principali: Eberling, Jamie L., Kells, Adrian P., Pivirotto, Philip, Beyer, Janine, Bringas, John, Federoff, Howard J., Forsayeth, John, Bankiewicz, Krystof S.
Natura: Artigo
Lingua:Inglês
Pubblicazione: Mary Ann Liebert, Inc. 2009
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2725183/
https://ncbi.nlm.nih.gov/pubmed/19254173
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1089/hum.2008.201
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