Safety Evaluation of AAV2-GDNF Gene Transfer into the Dopaminergic Nigrostriatal Pathway in Aged and Parkinsonian Rhesus Monkeys

We evaluated neuropathological findings in two studies of AAV2-GDNF efficacy and safety in naive aged (>20 years) or MPTP (1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine)-lesioned rhesus macaques. In the first study, a total of 17 animals received one of two doses of AAV2-GDNF into either putamen o...

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Hlavní autoři: Su, Xiaomin, Kells, Adrian P., Huang, Eric J., Lee, Han S., Hadaczek, Piotr, Beyer, Janine, Bringas, John, Pivirotto, Philip, Penticuff, Janine, Eberling, Jamie, Federoff, Howard J., Forsayeth, John, Bankiewicz, Krystof S.
Médium: Artigo
Jazyk:Inglês
Vydáno: Mary Ann Liebert, Inc. 2009
Témata:
Scientific Articles
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2861959/
https://ncbi.nlm.nih.gov/pubmed/19671001
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1089/hum.2009.103
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