Carbidopa-Based Modulation of the Functional Effect of the AAV2-hAADC Gene Therapy in 6-OHDA Lesioned Rats

Progressively blunted response to L-DOPA in Parkinson’s disease (PD) is a critical factor that complicates long-term pharmacotherapy in view of the central importance of this drug in management of the PD-related motor disturbance. This phenomenon is likely due to progressive loss of one of the key e...

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Udgivet i:PLoS One
Main Authors: Ciesielska, Agnieszka, Sharma, Nitasha, Beyer, Janine, Forsayeth, John, Bankiewicz, Krystof
Format: Artigo
Sprog:Inglês
Udgivet: Public Library of Science 2015
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4393141/
https://ncbi.nlm.nih.gov/pubmed/25860990
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0122708
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