Depletion of AADC activity in caudate nucleus and putamen of Parkinson’s disease patients; implications for ongoing AAV2-AADC gene therapy trial

In Parkinson’s disease (PD), aromatic L-amino acid decarboxylase (AADC) is the rate-limiting enzyme in the conversion of L-DOPA (Sinemet) to dopamine (DA). Previous studies in PD animal models demonstrated that lesion of dopaminergic neurons is associated with profound loss of AADC activity in the s...

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Veröffentlicht in:PLoS One
Hauptverfasser: Ciesielska, Agnieszka, Samaranch, Lluis, San Sebastian, Waldy, Dickson, Dennis W., Goldman, Samuel, Forsayeth, John, Bankiewicz, Krystof S.
Format: Artigo
Sprache:Inglês
Veröffentlicht: Public Library of Science 2017
Schlagworte:
Research Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5293261/
https://ncbi.nlm.nih.gov/pubmed/28166239
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0169965
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