An alpha-synuclein AAV gene silencing vector ameliorates a behavioral deficit in a rat model of Parkinson’s disease, but displays toxicity in dopamine neurons

Effects of silencing ectopically expressed hSNCA in rat substantia nigra (SN) were examined as a novel therapeutic approach to Parkinson’s disease (PD). AAV-hSNCA with or without an AAV harboring a short-hairpin (sh)RNA targeting hSNCA or luciferase was injected into one SN. At 9wks, hSNCA-expressin...

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Detalhes bibliográficos
Main Authors: Khodr, Christina E., Sapru, Mohan K., Pedapati, Jyothi, Han, Ye, West, Neva C., Kells, Adrian P., Bankiewicz, Krystof S., Bohn, Martha C.
Formato: Artigo
Idioma:Inglês
Publicado em: 2011
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3105182/
https://ncbi.nlm.nih.gov/pubmed/21565333
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.brainres.2011.04.036
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