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Inclusion of a portion of the native SNCA 3′UTR reduces toxicity of human S129A SNCA on striatal-projecting dopamine neurons in rat substantia nigra
Experimental models of Parkinson’s disease (PD) created by aberrant expression of the alpha-synuclein (SNCA) coding region have been reported. However, non-coding regions function in normal physiology and recent in vitro studies have shown that microRNAs-7 and -153 regulate SNCA expression by bindin...
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| Main Authors: | , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2012
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3361904/ https://ncbi.nlm.nih.gov/pubmed/22021082 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/dneu.20989 |
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