Over the barrier and through the blood; To CNS delivery we go

Por Foust, Kevin D., Kaspar, Brian K.
Publicado em 2009

Intravenous Injections in Neonatal Mice

Por Gombash Lampe, Sara E., Kaspar, Brian K., Foust, Kevin D.
Publicado no J Vis Exp (2014)

Endolysosomal Deficits Augment Mitochondria Pathology in Spinal Motor Neurons of Asymptomatic fALS Mice

Por Xie, Yuxiang, Zhou, Bing, Lin, Mei-Yao, Wang, Shiwei, Foust, Kevin D., Sheng, Zu-Hang
Publicado no Neuron (2015)

Intravascular AAV9 preferentially targets neonatal-neurons and adult-astrocytes in CNS

Por Foust, Kevin D., Nurre, Emily, Montgomery, Chrystal L., Hernandez, Anna, Chan, Curtis M., Kaspar, Brian K.
Publicado em 2008

Intravenous AAV9 efficiently transduces myenteric neurons in neonate and juvenile mice

Por Gombash, Sara E., Cowley, Christopher J., Fitzgerald, Julie A., Hall, Jodie C. E., Mueller, Christian, Christofi, Fedias L., Foust, Kevin D.
Publicado em 2014

Targeted Delivery of Self-Complementary Adeno-Associated Virus Serotype 9 to the Brain, Using Magnetic Resonance Imaging-Guided Focused Ultrasound

Por Thévenot, Emmanuel, Jordão, Jessica F., O'Reilly, Meaghan A., Markham, Kelly, Weng, Ying-Qi, Foust, Kevin D., Kaspar, Brian K., Hynynen, Kullervo, Aubert, Isabelle
Publicado em 2012

A single administration of morpholino antisense oligomer rescues spinal muscular atrophy in mouse

Por Porensky, Paul N., Mitrpant, Chalermchai, McGovern, Vicki L., Bevan, Adam K., Foust, Kevin D., Kaspar, Brain K., Wilton, Stephen D., Burghes, Arthur H.M.
Publicado em 2012

Adeno-Associated Virus Serotype 9 Transduction in the Central Nervous System of Nonhuman Primates

Por Samaranch, Lluis, Salegio, Ernesto A., San Sebastian, Waldy, Kells, Adrian P., Foust, Kevin D., Bringas, John R., Lamarre, Clementine, Forsayeth, John, Kaspar, Brian K., Bankiewicz, Krystof S.
Publicado em 2011

Therapeutic AAV9-mediated Suppression of Mutant SOD1 Slows Disease Progression and Extends Survival in Models of Inherited ALS

Por Foust, Kevin D, Salazar, Desirée L, Likhite, Shibi, Ferraiuolo, Laura, Ditsworth, Dara, Ilieva, Hristelina, Meyer, Kathrin, Schmelzer, Leah, Braun, Lyndsey, Cleveland, Don W, Kaspar, Brian K
Publicado em 2013

SMN expression is required in motor neurons to rescue electrophysiological deficits in the SMNΔ7 mouse model of SMA

Por McGovern, Vicki L., Iyer, Chitra C., Arnold, W. David, Gombash, Sara E., Zaworski, Phillip G., Blatnik, Anton J., Foust, Kevin D., Burghes, Arthur H.M.
Publicado no Hum Mol Genet (2015)

Systemic Delivery of MeCP2 Rescues Behavioral and Cellular Deficits in Female Mouse Models of Rett Syndrome

Por Garg, Saurabh K., Lioy, Daniel T., Cheval, Hélène, McGann, James C., Bissonnette, John M., Murtha, Matthew J., Foust, Kevin D., Kaspar, Brian K., Bird, Adrian, Mandel, Gail
Publicado em 2013

Low levels of Survival Motor Neuron protein are sufficient for normal muscle function in the SMNΔ7 mouse model of SMA

Por Iyer, Chitra C., McGovern, Vicki L., Murray, Jason D., Gombash, Sara E., Zaworski, Phillip G., Foust, Kevin D., Janssen, Paul M.L., Burghes, Arthur H.M.
Publicado no Hum Mol Genet (2015)

A role for glia in the progression of Rett syndrome

Por Lioy, Daniel T., Garg, Saurabh K., Monaghan, Caitlin E., Raber, Jacob, Foust, Kevin D., Kaspar, Brian K., Hirrlinger, Petra G., Kirchhoff, Frank, Bissonnette, John M., Ballas, Nurit, Mandel, Gail
Publicado em 2011

Nigrostriatal rAAV-mediated GDNF Overexpression Induces Robust Weight Loss in a Rat Model of Age-related Obesity

Por Manfredsson, Fredric P, Tumer, Nihal, Erdos, Benedek, Landa, Tessa, Broxson, Christopher S, Sullivan, Layla F, Rising, Aaron C, Foust, Kevin D, Zhang, Yi, Muzyczka, Nicholas, Gorbatyuk, Oleg S, Scarpace, Philip J, Mandel, Ronald J
Publicado em 2009

Rescue of the spinal muscular atrophy phenotype in a mouse model by early postnatal delivery of SMN

Por Foust, Kevin D, Wang, Xueyong, McGovern, Vicki L, Braun, Lyndsey, Bevan, Adam K, Haidet, Amanda M, Le, Thanh T, Morales, Pablo R, Rich, Mark M, Burghes, Arthur H M, Kaspar, Brian K
Publicado em 2010

Early heart failure in the SMNΔ7 model of spinal muscular atrophy and correction by postnatal scAAV9-SMN delivery

Por Bevan, Adam K., Hutchinson, Kirk R., Foust, Kevin D., Braun, Lyndsey, McGovern, Vicki L., Schmelzer, Leah, Ward, Jennifer G., Petruska, Jeffrey C., Lucchesi, Pamela A., Burghes, Arthur H.M., Kaspar, Brian K.
Publicado em 2010

MHC class I protects motor neurons from astrocyte-induced toxicity in amyotrophic lateral sclerosis (ALS)

Por Song, SungWon, Miranda, Carlos J., Braun, Lyndsey, Meyer, Kathrin, Frakes, Ashley E., Ferraiuolo, Laura, Likhite, Shibi, Bevan, Adam K., Foust, Kevin D., McConnell, Michael J., Walker, Christopher M., Kaspar, Brian K.
Publicado no Nat Med (2016)

Improving Single Injection CSF Delivery of AAV9-mediated Gene Therapy for SMA: A Dose–response Study in Mice and Nonhuman Primates

Por Meyer, Kathrin, Ferraiuolo, Laura, Schmelzer, Leah, Braun, Lyndsey, McGovern, Vicki, Likhite, Shibi, Michels, Olivia, Govoni, Alessandra, Fitzgerald, Julie, Morales, Pablo, Foust, Kevin D, Mendell, Jerry R, Burghes, Arthur H M, Kaspar, Brian K
Publicado no Mol Ther (2015)

SMN deficiency disrupts gastrointestinal and enteric nervous system function in mice

Por Gombash, Sara E., Cowley, Christopher J., Fitzgerald, Julie A., Iyer, Chitra C., Fried, David, McGovern, Vicki L., Williams, Kent C., Burghes, Arthur H.M., Christofi, Fedias L., Gulbransen, Brian D., Foust, Kevin D.
Publicado no Hum Mol Genet (2015)

SMN deficiency disrupts gastrointestinal and enteric nervous system function in mice

Por Gombash, Sara E., Cowley, Christopher J., Fitzgerald, Julie A., Iyer, Chitra C., Fried, David, McGovern, Vicki L., Williams, Kent C., Burghes, Arthur H.M., Christofi, Fedias L., Gulbransen, Brian D., Foust, Kevin D.
Publicado no Hum Mol Genet (2015)