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Intravascular AAV9 preferentially targets neonatal-neurons and adult-astrocytes in CNS

Delivery of therapeutics to the brain and spinal cord remains a challenge for neurodegenerative diseases, such as spinal muscular atrophy (SMA) and amyotrophic lateral sclerosis (ALS). The blood-brain-barrier (BBB) hampers delivery of therapeutics to neurons, glia, and surrounding cell types of the...

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Detalhes bibliográficos
Main Authors: Foust, Kevin D., Nurre, Emily, Montgomery, Chrystal L., Hernandez, Anna, Chan, Curtis M., Kaspar, Brian K.
Formato: Artigo
Idioma:Inglês
Publicado em: 2008
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2895694/
https://ncbi.nlm.nih.gov/pubmed/19098898
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nbt.1515
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