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Intravascular AAV9 preferentially targets neonatal-neurons and adult-astrocytes in CNS
Delivery of therapeutics to the brain and spinal cord remains a challenge for neurodegenerative diseases, such as spinal muscular atrophy (SMA) and amyotrophic lateral sclerosis (ALS). The blood-brain-barrier (BBB) hampers delivery of therapeutics to neurons, glia, and surrounding cell types of the...
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| Main Authors: | , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2008
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2895694/ https://ncbi.nlm.nih.gov/pubmed/19098898 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nbt.1515 |
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