Systemic Delivery of MeCP2 Rescues Behavioral and Cellular Deficits in Female Mouse Models of Rett Syndrome

De novo mutations in the X-linked gene encoding the transcription factor methyl-CpG binding protein 2 (MECP2) are the most frequent cause of the neurological disorder Rett syndrome (RTT). Hemizygous males usually die of neonatal encephalopathy. Heterozygous females survive into adulthood but exhibit...

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Main Authors: Garg, Saurabh K., Lioy, Daniel T., Cheval, Hélène, McGann, James C., Bissonnette, John M., Murtha, Matthew J., Foust, Kevin D., Kaspar, Brian K., Bird, Adrian, Mandel, Gail
Formato: Artigo
Idioma:Inglês
Publicado: Society for Neuroscience 2013
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Articles
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3755711/
https://ncbi.nlm.nih.gov/pubmed/23966684
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.1854-13.2013
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