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Partial rescue of MeCP2 deficiency by postnatal activation of MeCP2
In humans, mutations in the X-linked MECP2 gene, are the cause of Rett syndrome (RTT), a neurodevelopmental disorder that affects mainly girls. MeCP2 binds to methylated CpGs and is thought to act as a transcriptional repressor. In male mice, deletion or targeted mutation of Mecp2 leads to lethality...
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| Main Authors: | , , , |
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| 格式: | Artigo |
| 語言: | Inglês |
| 出版: |
National Academy of Sciences
2007
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| 主題: | |
| 在線閱讀: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1794312/ https://ncbi.nlm.nih.gov/pubmed/17267601 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0610593104 |
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