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Partial rescue of MeCP2 deficiency by postnatal activation of MeCP2

In humans, mutations in the X-linked MECP2 gene, are the cause of Rett syndrome (RTT), a neurodevelopmental disorder that affects mainly girls. MeCP2 binds to methylated CpGs and is thought to act as a transcriptional repressor. In male mice, deletion or targeted mutation of Mecp2 leads to lethality...

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Autors principals: Giacometti, Emanuela, Luikenhuis, Sandra, Beard, Caroline, Jaenisch, Rudolf
Format: Artigo
Idioma:Inglês
Publicat: National Academy of Sciences 2007
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC1794312/
https://ncbi.nlm.nih.gov/pubmed/17267601
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0610593104
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