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Expression of MeCP2 in postmitotic neurons rescues Rett syndrome in mice
Mutations in MECP2 are the cause of Rett syndrome (RTT) in humans, a neurodevelopmental disorder that affects mainly girls. MeCP2 is a protein that binds CpG dinucleotides and is thought to act as a global transcriptional repressor. It is highly expressed in neurons, but not in glia, of the postnata...
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| Main Authors: | , , , |
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| Format: | Artigo |
| Jezik: | Inglês |
| Izdano: |
National Academy of Sciences
2004
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| Teme: | |
| Online dostop: | https://ncbi.nlm.nih.gov/pmc/articles/PMC395918/ https://ncbi.nlm.nih.gov/pubmed/15069197 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0401626101 |
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