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Radically truncated MeCP2 rescues Rett syndrome-like neurological defects
Heterozygous mutations in the X-linked MECP2 gene cause the profound neurological disorder Rett syndrome (RTT)1. MeCP2 protein is an epigenetic reader whose binding to chromatin primarily depends on 5-methylcytosine (mC)2,3. Functionally, MeCP2 has been implicated in several cellular processes based...
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| Izdano u: | Nature |
|---|---|
| Glavni autori: | , , , , , , , , |
| Format: | Artigo |
| Jezik: | Inglês |
| Izdano: |
2017
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| Teme: | |
| Online pristup: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5884422/ https://ncbi.nlm.nih.gov/pubmed/29019980 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nature24058 |
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