Radically truncated MeCP2 rescues Rett syndrome-like neurological defects

Heterozygous mutations in the X-linked MECP2 gene cause the profound neurological disorder Rett syndrome (RTT)1. MeCP2 protein is an epigenetic reader whose binding to chromatin primarily depends on 5-methylcytosine (mC)2,3. Functionally, MeCP2 has been implicated in several cellular processes based...

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Udgivet i:Nature
Main Authors: Tillotson, Rebekah, Selfridge, Jim, Koerner, Martha V., Gadalla, Kamal K. E., Guy, Jacky, De Sousa, Dina, Hector, Ralph D., Cobb, Stuart R., Bird, Adrian
Format: Artigo
Sprog:Inglês
Udgivet: 2017
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5884422/
https://ncbi.nlm.nih.gov/pubmed/29019980
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nature24058
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